LipLearner: Customizable Silent Speech Interactions on Mobile Devices

Silent speech interface is a promising technology that enables private communications in natural language. However, previous approaches only support a small and inflexible vocabulary, which leads to limited expressiveness. We leverage contrastive learning to learn efficient lipreading representations, enabling few-shot command customization with minimal user effort. Our model exhibits high robustness to different lighting, posture, and gesture conditions on an in-the-wild dataset. For 25-command classification, an F1-score of 0.8947 is achievable only using one shot, and its performance can be further boosted by adaptively learning from more data. This generalizability allowed us to develop a mobile silent speech interface empowered with on-device fine-tuning and visual keyword spotting. A user study demonstrated that with LipLearner, users could define their own commands with high reliability guaranteed by an online incremental learning scheme. Subjective feedback indicated that our system provides essential functionalities for customizable silent speech interactions with high usability and learnability.Comment: Conditionally accepted to the ACM CHI Conference on Human Factors in Computing Systems 2023 (CHI '23

Adaptive Control of MEMS Gyroscope Based on T-S Fuzzy Model

A multi-input multioutput (MIMO) Takagi-Sugeno (T-S) fuzzy model is built on the basis of a nonlinear model of MEMS gyroscope. A reference model is adjusted so that a local linear state feedback controller could be designed for each T-S fuzzy submodel based on a parallel distributed compensation (PDC) method. A parameter estimation scheme for updating the parameters of the T-S fuzzy models is designed and analyzed based on the Lyapunov theory. A new adaptive law can be selected to be the former adaptive law plus a nonnegative in variable to guarantee that the derivative of the Lyapunov function is smaller than zero. The controller output is implemented on the nonlinear model and T-S fuzzy model, respectively, for the purpose of comparison. Numerical simulations are investigated to verify the effectiveness of the proposed control scheme and the correctness of the T-S fuzzy model

Estimation of mechanics parameters of rock in consideration of confining pressure using monitoring while drilling data

During the drilling process, high-strength rock can lead to various issues such as drilling suppression, bit wear, and increased operational costs. To ensure safe and efficient drilling operations, it is crucial to accurately predict the strength parameters of the rock and recommend modifications to operational procedures. This paper proposes a low-cost and fast measurement method for predicting the strength parameters of rock in the field. To evaluate the effectiveness of this method, a drilling process monitoring experiment was conducted on sandstone, limestone, and granite. The experiment studied the effect of confining pressure on the response of cutting with an impregnated diamond bit. By analyzing the relationship between the thrust force, torque force, and penetration depth under different confining pressures, the researchers developed an analytical model for drilling that considers confining pressure, compressed crushed zone, and bit geometry. The results show that the confining pressure has a significant effect on the cutting response. As the confining pressure increases, the thrust force, torque force, and penetration depth at the cutting point also increase. Furthermore, a new measurement method was proposed to determine the strength parameters, such as cohesion, internal friction angle, and unconfined compressive strength. The estimated strength parameters for the three rock types using the drilling method were in good agreement with those of the standard laboratory test, with an error range of 10%. This method of estimating rock strength parameters is a practical tool for engineers. It can continuously and quickly obtain the drilling parameters of in-situ rocks

Planetary Defense team project: READI (Roadmap for EArth Defense Initiatives)

Planetary Defense is a complex problem, not well understood by policy makers and the general public. The recent Chelyabinsk incident in Russia created temporary international attention but has failed to effectively stimulate public action. The lack of long-term attention to cosmic hazards has resulted in limited funding to defend our planet. Hence, it is hard to realistically address this challenge and achieve the high test and operational readiness needed for an effective Planetary Defense strategy. To address this problem, we have created a set of recommendations for the development of a Planetary Defense Program, for the purpose of contributing to the protection of Earth from asteroids and comets. The SSP15 READI Project focused on threats for which there is only a short-term warning, specifically a warning of two years or less from detection of the object to impact. We have provided recommendations in five areas of Planetary Defense including detection and tracking, deflection techniques, global collaboration, outreach and education, and evacuation and recovery. We have applied this set of recommendations in a narrative scenario to make our report more impactful and engaging. We contrast optimistic and pessimistic outcomes for a comet threat, differing from each other in terms of the level of readiness achieved during the years leading up to the discovery of the threat. In our optimistic scenario, the deflection system has achieved high test and operational readiness. The world’s governments have realized the importance of being prepared against cosmic hazards and put in place all of the necessary measures for a successful defense, leading to a positive deflection of the comet. In contrast, in the pessimistic scenario no preparation is done before the detection, and the comet strikes a heavily populated area releasing energy equivalent to 80 times the most powerful nuclear bomb ever detonated. The recommendations that we have identified in this report constitute a roadmap to avoid this horrible outcome, and we believe they should be taken seriously and swiftly implemented

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Linear Ubiquitination Mediates EGFR-Induced NF-κB Pathway and Tumor Development

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that instigates several signaling cascades, including the NF-κB signaling pathway, to induce cell differentiation and proliferation. Overexpression and mutations of EGFR are found in up to 30% of solid tumors and correlate with a poor prognosis. Although it is known that EGFR-mediated NF-κB activation is involved in tumor development, the signaling axis is not well elucidated. Here, we found that plakophilin 2 (PKP2) and the linear ubiquitin chain assembly complex (LUBAC) were required for EGFR-mediated NF-κB activation. Upon EGF stimulation, EGFR recruited PKP2 to the plasma membrane, and PKP2 bridged HOIP, the catalytic E3 ubiquitin ligase in the LUBAC, to the EGFR complex. The recruitment activated the LUBAC complex and the linear ubiquitination of NEMO, leading to IκB phosphorylation and subsequent NF-κB activation. Furthermore, EGF-induced linear ubiquitination was critical for tumor cell proliferation and tumor development. Knockout of HOIP impaired EGF-induced NF-κB activity and reduced cell proliferation. HOIP knockout also abrogated the growth of A431 epidermal xenograft tumors in nude mice by more than 70%. More importantly, the HOIP inhibitor, HOIPIN-8, inhibited EGFR-mediated NF-κB activation and cell proliferation of A431, MCF-7, and MDA-MB-231 cancer cells. Overall, our study reveals a novel linear ubiquitination signaling axis of EGFR and that perturbation of HOIP E3 ubiquitin ligase activity is potential targeted cancer therapy

Finite element analysis comparison of Type 42A2 fracture fixed with external titanium alloy locking plate and traditional external fixation frame

Abstract Background At present, not all Type AO/OTA 42A2 open fractures can be treated by external fixation brackets, not to mention the inconvenience of this technique in clinical practice. External titanium alloy locking plates, which are lightweight and easy-to-operate, can be used as an alternative treatment option for such patients. However, there are few reports of finite element biomechanical analysis on the titanium alloy locking plates and fixation brackets being placed on the medial side of the tibial fracture. In this study, the biomechanical properties of titanium alloy locking plates and fixation brackets for treating Type AO/OTA 42A2 fractures were compared by applying the finite element method, and the results provided data support for the clinical application of the external titanium alloy locking plate technique. Methods Type AO/OTA 42A2 fracture models were constructed using CT data of a male volunteer for two external fixation techniques, namely the external titanium alloy locking plate technique and the external fixation bracket technique, according to commonly-used clinical protocols. Then, the four-point bending, axial compression, clockwise rotation and counterclockwise rotation tests under the maximum load were simulated in finite element analysis software. The stress distribution, peak stress and overall tibial displacement data for the two different external fixation techniques were obtained and compared. Results In the four different test conditions (i.e., four-point bending, axial compression, clockwise torsion, counterclockwise torsion) under the maximum load, the two external fixation techniques showed obvious von Mises stress concentration at the contacts between the screw and tibia, between the screw and titanium alloy locking plate, between the self-tapping self-drilling needle and tibia, between the self-tapping self-drilling needle and the external fixation device, as well as around the fracture end and around the cortical bone at the upper and lower ends of the tibia. The peak stress was ranged 26.67–558.77 MPa, all below the yield stress strength of titanium alloy. The peak tibial displacement of the external titanium alloy locking plate model was smaller than that of the fixation bracket model. In terms of structural stability, the external titanium alloy locking plate technique was superior to the external fixation bracket technique. Conclusions When fixing Type AO/OTA 42A2 fractures, external titanium alloy locking plates are not only lightweight and easy-to-operate, but also have better performance in terms of axial compression, bending and torsion resistance. According to the finite element biomechanical analysis, external titanium alloy locking plates are superior to traditional external fixation brackets in treating Type AO/OTA 42A2 fractures and can better meet the needs of clinical application